Slitrks as emerging candidate genes involved in neuropsychiatric disorders.

TitleSlitrks as emerging candidate genes involved in neuropsychiatric disorders.
Publication TypeJournal Article
Year of Publication2011
AuthorsProenca CC, Gao KP, Shmelkov SV, Rafii S, Lee FS
JournalTrends Neurosci
Date Published2011 Mar
KeywordsAnimals, Disease Models, Animal, Genetic Predisposition to Disease, Humans, Membrane Proteins, Mental Disorders, Multigene Family, Nerve Tissue Proteins

Slitrks are a family of structurally related transmembrane proteins belonging to the leucine-rich repeat (LRR) superfamily. Six family members exist (Slitrk1-6) and all are highly expressed in the central nervous system (CNS). Slitrks have been implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival. Recent studies in humans and genetic mouse models have led to the identification of Slitrks as candidate genes that might be involved in the development of neuropsychiatric conditions, such as obsessive compulsive spectrum disorders and schizophrenia. Although these system-level approaches have suggested that Slitrks play prominent roles in CNS development, key questions remain regarding the molecular mechanisms through which they mediate neuronal signaling and connectivity.

Alternate JournalTrends Neurosci.
PubMed ID21315458
PubMed Central IDPMC3051006
Grant ListR01 NS052819 / NS / NINDS NIH HHS / United States
R01 NS052819-07 / NS / NINDS NIH HHS / United States